Colloquium: Compensated biventricular hypertrophy and arrhythmogenesis

24-04-2018

16.00 - 17.00 uur

VU main building - HG 8A33

Colloquium: Compensated biventricular hypertrophy and arrhythmogenesis

Prof. dr. M.A. (Marc) Vos

Faculteit der Gedrags- en Bewegingswetenschappen

Bewegingswetenschappen

Overig

Marc VosProf. dr. Marc Vos is professor and chair of the Department of Medical Physiology, Division Heart and Lungs, at the University Medical Center Utrecht (UMC) in The Netherlands. His research group carries out research into the mechanisms of cardiac arrhythmia. These abnormal heart rhythms arise in patients whose heart has changed due to an illness. The research is conducted at the molecular level and right up to the level of the patient as a whole. The aim is to enable doctors to estimate the risk of cardiac arrhythmias occurring. 

This problem cause fifteen thousand deaths every year in the Netherlands. We also use this technique to improve the treatment of cardiac arrhythmia to make it more effective and less intrusive for the patients.

Abstract
The heart adapts itself when body demands are changing, either acute or chronically. The latter adaptations are collectively called ventricular remodeling and include contractile, structural and electrical remodeling processes. When looking at the outcome, the cardiac output is often used to define the result: the heart is either (super)compensated or failing. However, a positive adaptation in one parameter / remodeling process does not have to imply that all processes do have the same benign signature. Using an animal model (the dog with chronic AV-block), it will be shown that although the contractile and structural remodeling processes adapt positively, there is an enhanced susceptibility for cardiac arrhythmias and sudden death that is partly caused by a negative electrical remodeling. The prolongation of the ventricular action potential reduces the repolarization strength of the heart (it’s reserve) and that makes the heart more vulnerable for afterdepolarizations when challenged. This feature is measurable and biomarkers are developed to identify the individuals at risk for these arrhythmias. 

This colloquium is organized by the department of Human Movement Sciences in collaboration with the research institute Amsterdam Movement Sciences.